1.1.31.1.1............Accession numbers: Bacterial Type III PKS

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LOCUS       AAZ93633                 371 aa            linear   BCT 31-DEC-2006
DEFINITION  type III polyketide synthase [Polyangium cellulosum].
ACCESSION   AAZ93633
VERSION     AAZ93633.1  GI:73918046
DBSOURCE    accession DQ156079.1
KEYWORDS    .
SOURCE      Sorangium cellulosum
  ORGANISM  Sorangium cellulosum
            Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
            Sorangiineae; Polyangiaceae; Sorangium.
REFERENCE   1  (residues 1 to 371)
  AUTHORS   Gross,F., Luniak,N., Gottschalk,D., Perlova,O., Gaitatzis,N.,
            Gerth,K., Jenke-Kodama,H., Dittmann,E. and Mueller,R.
  TITLE     Bacterial type III polyketide synthases: phylogenetic analysis and
            potential for the production of novel secondary metabolites by
            heterologous expression in Pseudomonads
  JOURNAL   Unpublished
REFERENCE   2  (residues 1 to 371)
  AUTHORS   Gross,F., Perlova,O., Bloecker,H., Puehler,A. and Mueller,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2005) Pharmaceutical Biotechnology, Saarland
            University, P.O. Box 151150, Saarbruecken 66041, Germany
COMMENT     Method: conceptual translation supplied by author.
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Sorangium cellulosum"
                     /strain="So ce56"
                     /db_xref="taxon:56"
     Protein         1..371
                     /product="type III polyketide synthase"
                     /EC_number="2.3.1.74"
     Region          19..368
                     /region_name="BcsA"
                     /note="Predicted naringenin-chalcone synthase [Secondary
                     metabolites biosynthesis, transport, and catabolism];
                     COG3424"
                     /db_xref="CDD:33230"
     Region          19..368
                     /region_name="CHS_like"
                     /note="Chalcone and stilbene synthases; plant-specific
                     polyketide synthases (PKS) and related enzymes, also
                     called type III PKSs. PKS generate an array of different
                     products, dependent on the nature of the starter molecule.
                     They share a common chemical...; cd00831"
                     /db_xref="CDD:29418"
     Site            order(54,57..58,216,260,299..301)
                     /site_type="other"
                     /note="malonyl-CoA binding site"
                     /db_xref="CDD:29418"
     Site            order(96..97,100,139..140,145,149,155..161,165..166,
                     175..176,179,182..184,237,239..241,251..254,362)
                     /site_type="other"
                     /note="dimer interface"
                     /db_xref="CDD:29418"
     Site            order(167,296,329)
                     /site_type="active"
                     /db_xref="CDD:29418"
     Site            order(195..197,217,249..251,259..260,331,359)
                     /site_type="other"
                     /note="product binding site"
                     /db_xref="CDD:29418"
     CDS             1..371
                     /gene="chs2"
                     /coded_by="DQ156079.1:1..1116"
                     /transl_table=11
ORIGIN      
        1 mhgddacrgs aaegrppata yinriatavp phdvhssfvr fastlfgder srvlfgrmad
       61 kaqishrfsv lapsaevgga sidagrfylr ggfpttadrm rlyekhapel aaqavagldl
      121 gsaarrithv ivtsctgfsa pgidlelver fgldpsvert migfmgcyaa inalklarhi
      181 vrsapearvl vvnvelctlh lqeavamdqm lsfllfgdgc aaavvsaepk glaldrlhav
      241 vvpgtrelit wnirdlgfem flsgrvpgai drglkaaaga ildgaapgei dlwavhpggr
      301 svldavehal dlgplalgas rdvlarfgnm ssatimfvlq sivadarpgm rgcamsfgpg
      361 ltaetvlfht a
//

Return to description: English - German

LOCUS       YP_001821984             350 aa            linear   BCT 08-MAY-2009
DEFINITION  type-III PKS [Streptomyces griseus subsp. griseus NBRC 13350].
ACCESSION   YP_001821984
VERSION     YP_001821984.1  GI:182434265
DBLINK      Project:20085
DBSOURCE    REFSEQ: accession NC_010572.1
KEYWORDS    .
SOURCE      Streptomyces griseus subsp. griseus NBRC 13350
  ORGANISM  Streptomyces griseus subsp. griseus NBRC 13350
            Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
            Streptomycineae; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ohnishi,Y., Ishikawa,J., Hara,H., Suzuki,H., Ikenoya,M., Ikeda,H.,
            Yamashita,A., Hattori,M. and Horinouchi,S.
  TITLE     Genome sequence of the streptomycin-producing microorganism
            Streptomyces griseus IFO 13350
  JOURNAL   J. Bacteriol. 190 (11), 4050-4060 (2008)
   PUBMED   18375553
REFERENCE   2
  AUTHORS   Funabashi,M., Funa,N. and Horinouchi,S.
  TITLE     Phenolic lipids synthesized by type III polyketide synthase confer
            penicillin resistance on Streptomyces griseus
  JOURNAL   J. Biol. Chem. 283 (20), 13983-13991 (2008)
   PUBMED   18364359
REFERENCE   3
  AUTHORS   Hirano,S., Tanaka,K., Ohnishi,Y. and Horinouchi,S.
  TITLE     Conditionally positive effect of the TetR-family transcriptional
            regulator AtrA on streptomycin production by Streptomyces griseus
  JOURNAL   Microbiology (Reading, Engl.) 154 (PT 3), 905-914 (2008)
   PUBMED   18310036
REFERENCE   4  (residues 1 to 350)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (10-APR-2008) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 350)
  AUTHORS   Hattori,M., Ohnishi,Y., Yamashita,A., Ishikawa,J., Ikeda,H. and
            Horinouchi,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2007) Contact:Masahira Hattori Graduate School of
            Frontier Sciences, The University of Tokyo; Kashiwanoha 5-1-5,
            Kashiwa, Chiba 277-8561, Japan URL
            :http://www.cb.k.u-tokyo.ac.jp/hattorilab/
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BAG17301.
            The complete and fully annotated sequences are also avaible at
            http://streptomyces.nih.go.jp/griseus/.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Streptomyces griseus subsp. griseus NBRC 13350"
                     /strain="NBRC 13350"
                     /sub_species="griseus"
                     /db_xref="taxon:455632"
                     /note="synonym: Streptomyces griseus subsp. griseus IFO
                     13350"
     Protein         1..350
                     /product="type-III PKS"
                     /calculated_mol_wt=37481
     Region          1..350
                     /region_name="BcsA"
                     /note="Predicted naringenin-chalcone synthase [Secondary
                     metabolites biosynthesis, transport, and catabolism];
                     COG3424"
                     /db_xref="CDD:33230"
     Region          1..348
                     /region_name="CHS_like"
                     /note="Chalcone and stilbene synthases; plant-specific
                     polyketide synthases (PKS) and related enzymes, also
                     called type III PKSs. PKS generate an array of different
                     products, dependent on the nature of the starter molecule.
                     They share a common chemical...; cd00831"
                     /db_xref="CDD:29418"
     Site            order(38,41..42,189,236,277..279)
                     /site_type="other"
                     /note="malonyl-CoA binding site"
                     /db_xref="CDD:29418"
     Site            order(66..67,70,111..112,117,121,127..133,137..138,
                     147..148,151,154..156,213,215..217,227..230,342)
                     /site_type="other"
                     /note="dimer interface"
                     /db_xref="CDD:29418"
     Site            order(139,274,307)
                     /site_type="active"
                     /db_xref="CDD:29418"
     Site            order(167..169,190,225..227,235..236,309,339)
                     /site_type="other"
                     /note="product binding site"
                     /db_xref="CDD:29418"
     CDS             1..350
                     /gene="srsA"
                     /locus_tag="SGR_472"
                     /coded_by="complement(NC_010572.1:550278..551330)"
                     /experiment="gene cloning and expression"
                     /transl_table=11
                     /db_xref="GeneID:6214239"
ORIGIN      
        1 mtriaavhga lpphrhtqre vtdlvartcl ppgadrrvld rlhenarvra rhtvlpldgy
       61 raldgfgatn dvfirsavdl garavrgalr saglrptdvd llmftsvtgi aapsvdarlv
      121 trlgmrsdvk rlpvfglgcv agaagtarlh dyllgrpddv avllsvelcs ltfqrhdasp
      181 anlvatalfg dgaaalvalg grravsgpei vatrsrmypd tehvmgwdvg stgfrvvldp
      241 avpdvvrqyl addvreflde hglkpkdvah wvchpggpkv leavtevldl pdgaldvtwr
      301 sladvgnlss ssvlhvlrdt ieqrrpepgt pglllamgpg fccelvllrw
//

-> RppA, THNS: 1,3,6,8-Tetrahydroxynaphthalene biosynthesis
Return to description: English - German

LOCUS       AAL78053                 367 aa            linear   BCT 14-JUN-2002
DEFINITION  RppA [Saccharopolyspora erythraea].
ACCESSION   AAL78053
VERSION     AAL78053.1  GI:20384882
DBSOURCE    accession AY078067.1
KEYWORDS    .
SOURCE      Saccharopolyspora erythraea
  ORGANISM  Saccharopolyspora erythraea
            Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
            Pseudonocardineae; Pseudonocardiaceae; Saccharopolyspora.
REFERENCE   1  (residues 1 to 367)
  AUTHORS   Cortes,J., Velasco,J., Foster,G., Blackaby,A.P., Rudd,B.A. and
            Wilkinson,B.
  TITLE     Identification and cloning of a type III polyketide synthase
            required for diffusible pigment biosynthesis in Saccharopolyspora
            erythraea
  JOURNAL   Mol. Microbiol. 44 (5), 1213-1224 (2002)
   PUBMED   12028378
REFERENCE   2  (residues 1 to 367)
  AUTHORS   Velasco,J., Cortes,J., Wilkinson,B. and Rudd,B.A.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-FEB-2002) Strategic Technologies, GlaxoSmithKline,
            Gunnels Wood Rd, Stevenage, Herts SG1 2NY, UK
FEATURES             Location/Qualifiers
     source          1..367
                     /organism="Saccharopolyspora erythraea"
                     /db_xref="taxon:1836"
     Protein         1..367
                     /product="RppA"
     Region          1..347
                     /region_name="BcsA"
                     /note="Predicted naringenin-chalcone synthase [Secondary
                     metabolites biosynthesis, transport, and catabolism];
                     COG3424"
                     /db_xref="CDD:33230"
     Region          1..343
                     /region_name="CHS_like"
                     /note="Chalcone and stilbene synthases; plant-specific
                     polyketide synthases (PKS) and related enzymes, also
                     called type III PKSs. PKS generate an array of different
                     products, dependent on the nature of the starter molecule.
                     They share a common chemical...; cd00831"
                     /db_xref="CDD:29418"
     Site            order(37,40..41,188,233,273..275)
                     /site_type="other"
                     /note="malonyl-CoA binding site"
                     /db_xref="CDD:29418"
     Site            order(65..66,69,110..111,116,120,126..132,136..137,
                     146..147,150,153..155,210,212..214,224..227,338)
                     /site_type="other"
                     /note="dimer interface"
                     /db_xref="CDD:29418"
     Site            order(138,270,303)
                     /site_type="active"
                     /db_xref="CDD:29418"
     Site            order(166..168,189,222..224,232..233,305,335)
                     /site_type="other"
                     /note="product binding site"
                     /db_xref="CDD:29418"
     CDS             1..367
                     /gene="rppA"
                     /coded_by="AY078067.1:3111..4214"
                     /transl_table=11
ORIGIN      
        1 mavlctpava vpehvitvee tldlarrvha dhpqlplvlr lisntgvrer hlirpiedtl
       61 ehpgfevrnr iyeeqakqrv pavvrealds aelgpedidl ivyvsctgfm mpsltawlin
      121 smgfrmstrq lpiaqlgcaa ggaainrahd fctaypdana livscefcsl cyqptdddig
      181 sllsnglfgd avgaavvrgh ggtgvrlern assmipeted wisyavkatg fhfqldkrvp
      241 ktmeplapal ralaedhrwd vagldfyvih aggprilddl tkflgvpsea frhsratlaq
      301 ygniasavvl dalrriieeg rlesgargmi agfgpgitae msvgtwvphd vllhgehstt
      361 sapggnr
//

-> RppA, THNS: Tetrahydroxynaphthalene biosynthesis
Return to description: English - German

LOCUS       BAA33495                 372 aa            linear   BCT 06-OCT-1998
DEFINITION  orf-1 [Streptomyces griseus].
ACCESSION   BAA33495
VERSION     BAA33495.1  GI:3702261
DBSOURCE    accession AB018074.1
KEYWORDS    .
SOURCE      Streptomyces griseus
  ORGANISM  Streptomyces griseus
            Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
            Streptomycineae; Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Ueda,K., Kim,K.M., Beppu,T. and Horinouchi,S.
  TITLE     Overexpression of a gene cluster encoding a chalcone synthase-like
            protein confers redbrown pigment production in Streptomyces griseus
  JOURNAL   J. Antibiot. 48 (7), 638-646 (1995)
   PUBMED   7649862
REFERENCE   2  (residues 1 to 372)
  AUTHORS   Ueda,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-OCT-1998) Kenji Ueda, The University of Tokyo,
            Faculty of Agriculture, Department of Agricultural Chemistry; 1-1-1
            Yayoi, Bunkyo-ku, Tokyo 113, Japan (Tel:03-3812-2111(ex.5147),
            Fax:03-3812-0544)
COMMENT     D45916:Submitted (13-Feb-1995).
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Streptomyces griseus"
                     /db_xref="taxon:1911"
     Protein         1..372
                     /name="orf-1"
     Region          1..348
                     /region_name="BcsA"
                     /note="Predicted naringenin-chalcone synthase [Secondary
                     metabolites biosynthesis, transport, and catabolism];
                     COG3424"
                     /db_xref="CDD:33230"
     Region          1..343
                     /region_name="CHS_like"
                     /note="Chalcone and stilbene synthases; plant-specific
                     polyketide synthases (PKS) and related enzymes, also
                     called type III PKSs. PKS generate an array of different
                     products, dependent on the nature of the starter molecule.
                     They share a common chemical...; cd00831"
                     /db_xref="CDD:29418"
     Site            order(37,40..41,188,233,273..275)
                     /site_type="other"
                     /note="malonyl-CoA binding site"
                     /db_xref="CDD:29418"
     Site            order(65..66,69,110..111,116,120,126..132,136..137,
                     146..147,150,153..155,210,212..214,224..227,338)
                     /site_type="other"
                     /note="dimer interface"
                     /db_xref="CDD:29418"
     Site            order(138,270,303)
                     /site_type="active"
                     /db_xref="CDD:29418"
     Site            order(166..168,189,222..224,232..233,305,335)
                     /site_type="other"
                     /note="product binding site"
                     /db_xref="CDD:29418"
     CDS             1..372
                     /gene="orf-1"
                     /coded_by="AB018074.1:1596..2714"
                     /note="similar to chalcone synthase"
                     /transl_table=11
ORIGIN      
        1 matlcrpaia vpehvitmqq tldlaretha ghpqrdlvlr liqntgvqtr hlvqpiektl
       61 ahpgfevrnq vyeaeaktrv pevvrralan aetepseidl ivyvsctgfm mpsltawiin
      121 smgfrpetrq lpiaqlgcaa ggaainrahd fcvaypdsnv livscefcsl cyqptdigvg
      181 sllsnglfgd alsaavvrgq ggtgmrlern gshlvpdted wisyavrdtg fhfqldkrvp
      241 gtmemlapvl ldlvdlhgws vpnmdffivh aggprilddl chfldlppem frysratlte
      301 rgniassvvf dalarlfddg gaaesaqgli agfgpgitae vavgswakeg lgadvgrdld
      361 eleltagval sg
//

-> diacetylphloroglucinol biosynthesis

Return to description: English - German

LOCUS AAB48106 349 aa linear BCT 18-MAY-1999

DEFINITION PhlD [Pseudomonas fluorescens].

ACCESSION AAB48106

VERSION AAB48106.1 GI:1163918

DBSOURCE locus PFU41818 accession U41818.1

KEYWORDS .

SOURCE Pseudomonas fluorescens

ORGANISM Pseudomonas fluorescens

Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;

Pseudomonadaceae; Pseudomonas.

REFERENCE 1 (residues 1 to 349)

AUTHORS Bangera,M.G. and Thomashow,L.S.

TITLE Identification and characterization of a gene cluster for synthesis

of the polyketide antibiotic 2,4-diacetylphloroglucinol from

Pseudomonas fluorescens Q2-87

JOURNAL J. Bacteriol. 181 (10), 3155-3163 (1999)

PUBMED 10322017

REFERENCE 2 (residues 1 to 349)

AUTHORS Thomashow,L.S. and Bangera,M.G.

TITLE Direct Submission

JOURNAL Submitted (29-NOV-1995) Linda S. Thomashow, Root Disease and

Biological Control Unit, United States Department of Agriculture,

Agriculture Research Service, Washington State University, 365

Johnson Hall, Pullman, WA 99164-6430, USA

COMMENT Method: conceptual translation.

FEATURES Location/Qualifiers

source 1..349

/organism="Pseudomonas fluorescens"

/strain="Q2-87"

/db_xref="taxon:294"

Protein 1..349

/product="PhlD"

Region 1..344

/region_name="CHS_like"

/note="Chalcone and stilbene synthases; plant-specific

polyketide synthases (PKS) and related enzymes, also

called type III PKSs. PKS generate an array of different

products, dependent on the nature of the starter molecule.

They share a common chemical...; cd00831"

/db_xref="CDD:29418"

Region 12..349

/region_name="BcsA"

/note="Predicted naringenin-chalcone synthase [Secondary

metabolites biosynthesis, transport, and catabolism];

COG3424"

/db_xref="CDD:33230"

Site order(37,40..41,188,234,275..277)

/site_type="other"

/note="malonyl-CoA binding site"

/db_xref="CDD:29418"

Site order(65..66,69,110..111,116,120,126..132,136..137,

146..147,150,153..155,211,213..215,225..228,339)

/site_type="other"

/note="dimer interface"

/db_xref="CDD:29418"

Site order(138,272,305)

/site_type="active"

/db_xref="CDD:29418"

Site order(166..168,189,223..225,233..234,307,336)

/site_type="other"

/note="product binding site"

/db_xref="CDD:29418"

CDS 1..349

/gene="phlD"

/coded_by="complement(U41818.1:1810..2859)"

/note="similar to chalcone synthase and stilbene

synthases; putative synthase"

/transl_table=11

ORIGIN

1 mstlckpsll fphykitqqq midhleqlhd dhprmalakr miqntqvner ylvlpidela

61 vhtgfthrsi vyerearrms siaarqaien aglttddirm vavtsctgfm mpsltahlin

121 dlglrtstvq lpiaqlgcva gaaainrand faslspdnha livslefssl cyqpqdtklh

181 afisaalfgd avsacvmrad dkapgfkiak tgsyflpdse hyikydvkds gfhftldkav

241 mnsikdvapm meelnfetfn qhcaqndffi fhtggrkild elvlqldlep grvaqsrdsl

301 seagniasvv vfdvlkrqfd sgpangatgm laafgpgfta emavgkwva

-> Diacetylphloroglucinol biosynthesis

Return to description: English - German

LOCUS AAM27403 349 aa linear BCT 13-MAY-2002

DEFINITION PhlD [Pseudomonas fluorescens].

ACCESSION AAM27403

VERSION AAM27403.1 GI:20531166

DBSOURCE accession AF497760.1

KEYWORDS .

SOURCE Pseudomonas fluorescens

ORGANISM Pseudomonas fluorescens

Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;

Pseudomonadaceae; Pseudomonas.

REFERENCE 1 (residues 1 to 349)

AUTHORS Abbas,A., Morrissey,J.P., Marquez,P.C., Sheehan,M.M., Delany,I.R.

and O'Gara,F.

TITLE Characterization of interactions between the transcriptional

repressor PhlF and its binding site at the phlA promoter in

Pseudomonas fluorescens F113

JOURNAL J. Bacteriol. 184 (11), 3008-3016 (2002)

PUBMED 12003942

REFERENCE 2 (residues 1 to 349)

AUTHORS Delany,I.R., Abbas,A., Marquez,P.C. and O'Gara,F.

TITLE Direct Submission

JOURNAL Submitted (02-APR-2002) Microbiology, UCC, College Road, Cork,

Ireland

COMMENT Method: conceptual translation.

FEATURES Location/Qualifiers

source 1..349

/organism="Pseudomonas fluorescens"

/strain="F113"

/db_xref="taxon:294"

/note="biocontrol strain; very efficient against Pythium

ultimum"

Protein 1..349

/product="PhlD"

Region 1..344

/region_name="CHS_like"

/note="Chalcone and stilbene synthases; plant-specific

polyketide synthases (PKS) and related enzymes, also

called type III PKSs. PKS generate an array of different

products, dependent on the nature of the starter olecule.

They share a common chemical...; cd00831"

/db_xref="CDD:29418"

Region 12..349

/region_name="BcsA"

/note="Predicted naringenin-chalcone synthase [Secondary

metabolites biosynthesis, transport, and catabolism];

COG3424"

/db_xref="CDD:33230"

Site order(37,40..41,188,234,275..277)

/site_type="other"

/note="malonyl-CoA binding site"

/db_xref="CDD:29418"

Site order(65..66,69,110..111,116,120,126..132,136..137,

146..147,150,153..155,211,213..215,225..228,339)

/site_type="other"

/note="dimer interface"

/db_xref="CDD:29418"

Site order(138,272,305)

/site_type="active"

/db_xref="CDD:29418"

Site order(166..168,189,223..225,233..234,307,336)

/site_type="other"

/note="product binding site"

/db_xref="CDD:29418"

CDS 1..349

/coded_by="AF497760.1:4346..5395"

/transl_table=11

ORIGIN

1 mstlckpsll fpqykitqqq miehleqlhd dhprmalakr miqntqvner hlvlpidela

61 vhtgfthrsi vyerearrms siaarqaien aglttddirm vavtsctgfm mpsltahlin

121 dlglrtstvq lpiaqlgcva gaaainrand fasrapdnhv livslefssl cyqpqdtklh

181 afisaalfgd avsacvmrad dqapgfkiak tgsyflpdse hyikydvkds gfhftldkav

241 mnsikdvapm meelnyetfn qhcaqndffi fhtggrkild elvlqldlep grvaqsrdsl

301 seagniatvv vfdvlkrqfd sglvdgatgm laafgpgfta emavgkwva

1,3,6,8-tetrahydroxynaphthalene synthase (THNS)

Return to description: English - German

LOCUS NP_625495 374 aa linear BCT 30-APR-2009

DEFINITION polyketide synthase [Streptomyces coelicolor A3(2)].

ACCESSION NP_625495

VERSION NP_625495.1 GI:21219716

DBLINK Project:242

DBSOURCE REFSEQ: accession NC_003888.3

KEYWORDS complete genome.

SOURCE Streptomyces coelicolor A3(2)

ORGANISM Streptomyces coelicolor A3(2)

Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;

Streptomycineae; Streptomycetaceae; Streptomyces.

REFERENCE 1 (residues 1 to 374)

AUTHORS Bentley,S.D., Chater,K.F., Cerdeno-Tarraga,A.M., Challis,G.L.,

Thomson,N.R., James,K.D., Harris,D.E., Quail,M.A., Kieser,H.,

Harper,D., Bateman,A., Brown,S., Chandra,G., Chen,C.W., Collins,M.,

Cronin,A., Fraser,A., Goble,A., Hidalgo,J., Hornsby,T., Howarth,S.,

Huang,C.H., Kieser,T., Larke,L., Murphy,L., Oliver,K., O'Neil,S.,

Rabbinowitsch,E., Rajandream,M.A., Rutherford,K., Rutter,S.,

Seeger,K., Saunders,D., Sharp,S., Squares,R., Squares,S.,

Taylor,K., Warren,T., Wietzorrek,A., Woodward,J., Barrell,B.G.,

Parkhill,J. and Hopwood,D.A.

TITLE Complete genome sequence of the model actinomycete Streptomyces

coelicolor A3(2)

JOURNAL Nature 417 (6885), 141-147 (2002)

PUBMED 12000953

REFERENCE 2 (residues 1 to 374)

AUTHORS Redenbach,M., Kieser,H.M., Denapaite,D., Eichner,A., Cullum,J.,

Kinashi,H. and Hopwood,D.A.

TITLE A set of ordered cosmids and a detailed genetic and physical map

for the 8 Mb Streptomyces coelicolor A3(2) chromosome

JOURNAL Mol. Microbiol. 21 (1), 77-96 (1996)

PUBMED 8843436

REFERENCE 3 (residues 1 to 374)

CONSRTM NCBI Genome Project

TITLE Direct Submission

JOURNAL Submitted (28-MAY-2002) National Center for Biotechnology

Information, NIH, Bethesda, MD 20894, USA

REFERENCE 4 (residues 1 to 374)

AUTHORS Bentley,S.D.

TITLE Direct Submission

JOURNAL Submitted (09-MAY-2002) Sanger Institute, Wellcome Trust Genome

Campus, Hinxton, Cambridge CB10 1SA, United Kingdom

COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final

NCBI review. The reference sequence was derived from CAC01488.

Method: conceptual translation.

FEATURES Location/Qualifiers

source 1..374

/organism="Streptomyces coelicolor A3(2)"

/strain="A3(2)"

/db_xref="taxon:100226"

Protein 1..374

/product="polyketide synthase"

/calculated_mol_wt=40803

Region 1..346

/region_name="BcsA"

/note="Predicted naringenin-chalcone synthase [Secondary

metabolites biosynthesis, transport, and catabolism];

COG3424"

/db_xref="CDD:33230"

Region 1..343

/region_name="CHS_like"

/note="Chalcone and stilbene synthases; plant-specific

polyketide synthases (PKS) and related enzymes, also

called type III PKSs. PKS generate an array of different

products, dependent on the nature of the starter molecule.

They share a common chemical...; cd00831"

/db_xref="CDD:29418"

Site order(37,40..41,188,233,273..275)

/site_type="other"

/note="malonyl-CoA binding site"

/db_xref="CDD:29418"

Site order(65..66,69,110..111,116,120,126..132,136..137,

146..147,150,153..155,210,212..214,224..227,338)

/site_type="other"

/note="dimer interface"

/db_xref="CDD:29418"

Site order(138,270,303)

/site_type="active"

/db_xref="CDD:29418"

Site order(166..168,222..224,232..233,305,335)

/site_type="other"

/note="product binding site"

/db_xref="CDD:29418"

CDS 1..374

/locus_tag="SCO1206"

/gene_synonym="2SCG58.06"

/coded_by="NC_003888.3:1277625..1278749"

/note="2SCG58.06, possible polyketide synthase, len: 374

aa; highly similar to TR:Q54240 (EMBL:AB018074)

Streptomyces griseus ORF-1 protein similar to chalcone

synthase, 372 aa; fasta scores: opt: 1769 z-score: 1998.4

E(): 0; 70.4% identity in 361 aa overlap and to

SW:CHSJ_PETHY (EMBL:X14597) Petunia hybrida chalcone

synthase J (EC 2.3.1.74) ChsJ, 389 aa; fasta scores: opt:

412 z-score: 469.3 E(): 1.1e-18; 29.5% identity in 312 aa

overlap. Contains Pfam match to entry PF00195

Chal_stil_synt, Chalcone and stilbene synthases"

/transl_table=11

/db_xref="GeneID:1096629"

ORIGIN

1 matlcrpsvs vpehvitmee tlelarrrht dhpqlplalr lientgvrtr hivqpiedtl

61 ehpgfedrnk vyereaksrv paviqraldd aellatdidv iiyvsctgfm mpsltawlin

121 emgfdsttrq ipiaqlgcaa ggaainrahd fctaypeana livacefcsl cyqptdlgvg

181 sllcnglfgd giaaavvrgr ggtgvrlern gsylipkted wimydvkatg fhflldkrvp

241 atmeplapal kelagehgwd asdldfyivh aggprilddl stflevdpha frfsratlte

301 ygniasavvl dalrrlfdeg gveegargll agfgpgitae mslgcwqtad vrrgirqdvt

361 rtaargvsrr vrqa

Return to description: English - German

LOCUS NP_390087 365 aa linear BCT 25-APR-2009

DEFINITION naringenin-chalcone synthase [Bacillus subtilis subsp. subtilis

str. 168].

ACCESSION NP_390087

VERSION NP_390087.1 GI:16079263

DBLINK Project:76

DBSOURCE REFSEQ: accession NC_000964.2

KEYWORDS complete genome.

SOURCE Bacillus subtilis subsp. subtilis str. 168

ORGANISM Bacillus subtilis subsp. subtilis str. 168

Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.

REFERENCE 1 (residues 1 to 365)

AUTHORS Kunst,F., Ogasawara,N., Moszer,I., Albertini,A.M., Alloni,G.,

Azevedo,V., Bertero,M.G., Bessieres,P., Bolotin,A., Borchert,S.,

Borriss,R., Boursier,L., Brans,A., Braun,M., Brignell,S.C.,

Bron,S., Brouillet,S., Bruschi,C.V., Caldwell,B., Capuano,V.,

Carter,N.M., Choi,S.K., Codani,J.J., Connerton,I.F., Cummings,N.J.,

Daniel,R.A., Denizot,F., Devine,K.M., Dusterhoft,A., Ehrlich,S.D.,

Emmerson,P.T., Entian,K.D., Errington,J., Fabret,C., Ferrari,E.,

Foulger,D., Fritz,C., Fujita,M., Fujita,Y., Fuma,S., Galizzi,A.,

Galleron,N., Ghim,S.Y., Glaser,P., Goffeau,A., Golightly,E.J.,

Grandi,G., Guiseppi,G., Guy,B.J., Haga,K., Haiech,J., Harwood,C.R.,

Henaut,A., Hilbert,H., Holsappel,S., Hosono,S., Hullo,M.F.,

Itaya,M., Jones,L., Joris,B., Karamata,D., Kasahara,Y.,

Klaerr-Blanchard,M., Klein,C., Kobayashi,Y., Koetter,P.,

Koningstein,G., Krogh,S., Kumano,M., Kurita,K., Lapidus,A.,

Lardinois,S., Lauber,J., Lazarevic,V., Lee,S.M., Levine,A., Liu,H.,

Masuda,S., Mauel,C., Medigue,C., Medina,N., Mellado,R.P.,

Mizuno,M., Moestl,D., Nakai,S., Noback,M., Noone,D., O'Reilly,M.,

Ogawa,K., Ogiwara,A., Oudega,B., Park,S.H., Parro,V., Pohl,T.M.,

Portetelle,D., Porwollik,S., Prescott,A.M., Presecan,E., Pujic,P.,

Purnelle,B., Rapoport,G., Rey,M., Reynolds,S., Rieger,M.,

Rivolta,C., Rocha,E., Roche,B., Rose,M., Sadaie,Y., Sato,T.,

Scanlan,E., Schleich,S., Schroeter,R., Scoffone,F., Sekiguchi,J.,

Sekowska,A., Seror,S.J., Serror,P., Shin,B.S., Soldo,B.,

Sorokin,A., Tacconi,E., Takagi,T., Takahashi,H., Takemaru,K.,

Takeuchi,M., Tamakoshi,A., Tanaka,T., Terpstra,P., Tognoni,A.,

Tosato,V., Uchiyama,S., Vandenbol,M., Vannier,F., Vassarotti,A.,

Viari,A., Wambutt,R., Wedler,E., Wedler,H., Weitzenegger,T.,

Winters,P., Wipat,A., Yamamoto,H., Yamane,K., Yasumoto,K., Yata,K.,

Yoshida,K., Yoshikawa,H.F., Zumstein,E., Yoshikawa,H. and

Danchin,A.

TITLE The complete genome sequence of the gram-positive bacterium

Bacillus subtilis

JOURNAL Nature 390 (6657), 249-256 (1997)

PUBMED 9384377

REFERENCE 2 (residues 1 to 365)

CONSRTM NCBI Genome Project

TITLE Direct Submission

JOURNAL Submitted (12-OCT-2001) National Center for Biotechnology

Information, NIH, Bethesda, MD 20894, USA

REFERENCE 3 (residues 1 to 365)

AUTHORS Kunst,F., Ogasawara,N., Yoshikawa,H. and Danchin,A.

TITLE Direct Submission

JOURNAL Submitted (18-NOV-1997) Institut Pasteur, Regulation de

l'Expression Genetique, 28 rue du Docteur Roux, Paris Cedex 15

75724, France

COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final

NCBI review. The reference sequence was derived from CAB14122.

Method: conceptual translation.

FEATURES Location/Qualifiers

source 1..365

/organism="Bacillus subtilis subsp. subtilis str. 168"

/strain="168"

/db_xref="taxon:224308"

Protein 1..365

/product="naringenin-chalcone synthase"

/EC_number="2.3.1.74"

/function="phenylalanine metabolism"

/calculated_mol_wt=40582

Region 1..365

/region_name="BcsA"

/note="Predicted naringenin-chalcone synthase [Secondary

metabolites biosynthesis, transport, and catabolism];

COG3424"

/db_xref="CDD:33230"

Region 1..359

/region_name="CHS_like"

/note="Chalcone and stilbene synthases; plant-specific

polyketide synthases (PKS) and related enzymes, also

called type III PKSs. PKS generate an array of different

products, dependent on the nature of the starter molecule.

They share a common chemical...; cd00831"

/db_xref="CDD:29418"

Site order(38,41..42,194,247,288..290)

/site_type="other"

/note="malonyl-CoA binding site"

/db_xref="CDD:29418"

Site order(66..67,70,116..117,122,126,132..138,142..143,

152..153,156,159..161,224,226..228,238..241,353)

/site_type="other"

/note="dimer interface"

/db_xref="CDD:29418"

Site order(144,285,318)

/site_type="active"

/db_xref="CDD:29418"

Site order(172..174,195,236..238,246..247,320,350)

/site_type="other"

/note="product binding site"

/db_xref="CDD:29418"

CDS 1..365

/gene="bcsA"

/locus_tag="BSU22050"

/coded_by="complement(NC_000964.2:2316153..2317250)"

/transl_table=11

/db_xref="GOA:P54157"

/db_xref="UniProtKB/Swiss-Prot:P54157"

/db_xref="GeneID:939069"

ORIGIN

1 mafilsigts lpaynvnqek aaefarymfq hsfkdidrll ssfkngqihs rqfvkpiewy

61 keghsfeekn qiyieetlkh sraavrecls hpeffqeaip yekveavffv sstglstpsi

121 earlmnelpf spytkripiw glgcaggasg laraaeycka ypeafvlvis aelcsltfqp

181 edktksnlig tslfgdgiaa allcgekadr rvsklklapk imdaqsvlmk qsedvmgwdf

241 tdqgfkvifs rdiptlvekw lktnvqifld khklsfhdis vflahpggkk vidayikslg

301 lsseklssaq silqkhgnms satilyvikd hlqnghkkea ergligalgp gfsselllfs

361 wekga

Return to description PKS10: English - German

LOCUS NP_216176 353 aa linear BCT 24-APR-2009

DEFINITION chalcone synthase [Mycobacterium tuberculosis H37Rv].

ACCESSION NP_216176

VERSION NP_216176.1 GI:15608798

DBLINK Project:224

DBSOURCE REFSEQ: accession NC_000962.2

KEYWORDS complete genome.

SOURCE Mycobacterium tuberculosis H37Rv

ORGANISM Mycobacterium tuberculosis H37Rv

Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;

Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium

tuberculosis complex.

REFERENCE 1

AUTHORS Camus,J.C., Pryor,M.J., Medigue,C. and Cole,S.T.

TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis

H37Rv

JOURNAL Microbiology (Reading, Engl.) 148 (Pt 10), 2967-2973 (2002)

PUBMED 12368430

REFERENCE 2 (residues 1 to 353)

AUTHORS Cole,S.T., Brosch,R., Parkhill,J., Garnier,T., Churcher,C.,

Harris,D., Gordon,S.V., Eiglmeier,K., Gas,S., Barry,C.E. III,

Tekaia,F., Badcock,K., Basham,D., Brown,D., Chillingworth,T.,

Connor,R., Davies,R., Devlin,K., Feltwell,T., Gentles,S.,

Hamlin,N., Holroyd,S., Hornsby,T., Jagels,K., Krogh,A., McLean,J.,

Moule,S., Murphy,L., Oliver,K., Osborne,J., Quail,M.A.,

Rajandream,M.A., Rogers,J., Rutter,S., Seeger,K., Skelton,J.,

Squares,R., Squares,S., Sulston,J.E., Taylor,K., Whitehead,S. and

Barrell,B.G.

TITLE Deciphering the biology of Mycobacterium tuberculosis from the

complete genome sequence

JOURNAL Nature 393 (6685), 537-544 (1998)

PUBMED 9634230

REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]

REFERENCE 3 (residues 1 to 353)

CONSRTM NCBI Genome Project

TITLE Direct Submission

JOURNAL Submitted (13-SEP-2001) National Center for Biotechnology

Information, NIH, Bethesda, MD 20894, USA

COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final

NCBI review. The reference sequence was derived from CAB06631.

Method: conceptual translation.

FEATURES Location/Qualifiers

source 1..353

/organism="Mycobacterium tuberculosis H37Rv"

/strain="H37Rv"

/db_xref="taxon:83332"

Protein 1..353

/product="chalcone synthase"

/EC_number="2.3.1.74"

/function="Possibly involved in the biosynthesis of

Secondary Metabolites [CATALYTIC ACTIVITY: 3 Malonyl-CoA +

4-Coumaroyl-CoA = 4 CoA + Naringenin chalcone + 3 CO2]"

/calculated_mol_wt=37015

Region 1..353

/region_name="BcsA"

/note="Predicted naringenin-chalcone synthase [Secondary

metabolites biosynthesis, transport, and catabolism];

COG3424"

/db_xref="CDD:33230"

Region 1..350

/region_name="CHS_like"

/note="Chalcone and stilbene synthases; plant-specific

polyketide synthases (PKS) and related enzymes, also

called type III PKSs. PKS generate an array of different

products, dependent on the nature of the starter molecule.

They share a common chemical...; cd00831"

/db_xref="CDD:29418"

Site order(40..41,188,239,280..282)

/site_type="other"

/note="malonyl-CoA binding site"

/db_xref="CDD:29418"

Site order(65..66,69,110..111,116,120,126..132,136..137,

146..147,150,153..155,216,218..220,230..233,344)

/site_type="other"

/note="dimer interface"

/db_xref="CDD:29418"

Site order(138,277,310)

/site_type="active"

/db_xref="CDD:29418"

Site order(166..168,189,228..230,238..239,312,341)

/site_type="other"

/note="product binding site"

/db_xref="CDD:29418"

CDS 1..353

/gene="pks10"

/locus_tag="Rv1660"

/coded_by="NC_000962.2:1874160..1875221"

/experiment="experimental evidence, no additional details

recorded"

/note="Rv1660, (MTCY06H11.25), len: 353 aa. Possible

pks10, chalcone synthase (EC 2.3.1.74), similar to

BCSA_BACSU|P54157 putative chalcone synthase from B.

subtilis (365 aa), FASTA scores: opt: 701, E(): 0, (33.1%

identity in 362 aa overlap). Also similar to M.

tuberculosis Rv1665|pks11 polyketide synthase (chalcone

synthase); and Rv1372|pks18 polyketide synthase. Other

upstream initiation sites are possible but homology

suggests this start."

/transl_table=11

/db_xref="GOA:P94995"

/db_xref="UniProtKB/TrEMBL:P94995"

/db_xref="GeneID:885112"

ORIGIN

1 msviagvfga lppyrysqre ltdsfvsipd fegyedivrq lhasakvnsr hlvlplekyp

61 kltdfgeank ifiekavdlg vqalagalde sglrpedldv litatvtgla vpsldariag

121 rlglradvrr vplfglgcva gaagvarlhd ylrgapdgva alvsvelcsl typgykptlp

181 glvgsalfad gaaavvaagv kraqdigadg pdildsrshl ypdslrtmgy dvgsagfelv

241 lsrdlaavve qylgndvttf lashglsttd vgawvthpgg pkiinaitet ldlspqalel

301 twrslgeign lssasvlhvl rdtiakppps gspglmiamg pgfcselvll rwh

Return to description PKS11: English - German

LOCUS NP_216181 353 aa linear BCT 24-APR-2009

DEFINITION chalcone synthase [Mycobacterium tuberculosis H37Rv].

ACCESSION NP_216181

VERSION NP_216181.1 GI:15608803

DBLINK Project:224

DBSOURCE REFSEQ: accession NC_000962.2

KEYWORDS complete genome.

SOURCE Mycobacterium tuberculosis H37Rv

ORGANISM Mycobacterium tuberculosis H37Rv

Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;

Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium

tuberculosis complex.

REFERENCE 1

AUTHORS Camus,J.C., Pryor,M.J., Medigue,C. and Cole,S.T.

TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis

H37Rv

JOURNAL Microbiology (Reading, Engl.) 148 (Pt 10), 2967-2973 (2002)

PUBMED 12368430

REFERENCE 2 (residues 1 to 353)

AUTHORS Cole,S.T., Brosch,R., Parkhill,J., Garnier,T., Churcher,C.,

Harris,D., Gordon,S.V., Eiglmeier,K., Gas,S., Barry,C.E. III,

Tekaia,F., Badcock,K., Basham,D., Brown,D., Chillingworth,T.,

Connor,R., Davies,R., Devlin,K., Feltwell,T., Gentles,S.,

Hamlin,N., Holroyd,S., Hornsby,T., Jagels,K., Krogh,A., McLean,J.,

Moule,S., Murphy,L., Oliver,K., Osborne,J., Quail,M.A.,

Rajandream,M.A., Rogers,J., Rutter,S., Seeger,K., Skelton,J.,

Squares,R., Squares,S., Sulston,J.E., Taylor,K., Whitehead,S. and

Barrell,B.G.

TITLE Deciphering the biology of Mycobacterium tuberculosis from the

complete genome sequence

JOURNAL Nature 393 (6685), 537-544 (1998)

PUBMED 9634230

REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]

REFERENCE 3 (residues 1 to 353)

CONSRTM NCBI Genome Project

TITLE Direct Submission

JOURNAL Submitted (13-SEP-2001) National Center for Biotechnology

Information, NIH, Bethesda, MD 20894, USA

COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final

NCBI review. The reference sequence was derived from CAB09101.

Method: conceptual translation.

FEATURES Location/Qualifiers

source 1..353

/organism="Mycobacterium tuberculosis H37Rv"

/strain="H37Rv"

/db_xref="taxon:83332"

Protein 1..353

/product="chalcone synthase"

/EC_number="2.3.1.74"

/function="Possibly involved in the biosynthesis of

Secondary Metabolites [CATALYTIC ACTIVITY: 3 Malonyl-CoA +

4-Coumaroyl-CoA = 4 CoA + Naringenin chalcone + 3 CO2]"

/calculated_mol_wt=37508

Region 1..353

/region_name="BcsA"

/note="Predicted naringenin-chalcone synthase [Secondary

metabolites biosynthesis, transport, and catabolism];

COG3424"

/db_xref="CDD:33230"

Region 1..350

/region_name="CHS_like"

/note="Chalcone and stilbene synthases; plant-specific

polyketide synthases (PKS) and related enzymes, also

called type III PKSs. PKS generate an array of different

products, dependent on the nature of the starter molecule.

They share a common chemical...; cd00831"

/db_xref="CDD:29418"

Site order(40..41,188,239,280..282)

/site_type="other"

/note="malonyl-CoA binding site"

/db_xref="CDD:29418"

Site order(65..66,69,110..111,116,120,126..132,136..137,

146..147,150,153..155,216,218..220,230..233,344)

/site_type="other"

/note="dimer interface"

/db_xref="CDD:29418"

Site order(138,277,310)

/site_type="active"

/db_xref="CDD:29418"

Site order(166..168,189,228..230,238..239,312,341)

/site_type="other"

/note="product binding site"

/db_xref="CDD:29418"

CDS 1..353

/gene="pks11"

/locus_tag="Rv1665"

/coded_by="NC_000962.2:1891226..1892287"

/note="Rv1665, (MTCY275.04-MTV047.01), len 353 aa.

Possible pks11, chalcone synthase (EC 2.3.1.74), some

similarity to BCSA_BACSU|P54157 putative chalcone synthase

from Bacillus subtilis (365 aa), FASTA scores: opt: 615,

E(): 6.2e-32, (33.4% identity in 308 aa overlap); and to

many plant chalcone synthases e.g. CHS_VIGUN|P51089

chalcone synthase (EC 2.3.1.74) (388 aa), FASTA scores:

opt: 391, E(): 7.8e-18, (27.2% identity in 349 aa

overlap). Highly similar to upstream ORF

Rv1660|MTCY06H11.25 pks10 (72.7% identity in 308 aa

overlap); and Rv1372 pks18."

/transl_table=11

/db_xref="GOA:O06587"

/db_xref="UniProtKB/TrEMBL:O06587"

/db_xref="GeneID:885525"

ORIGIN

1 msviagvfga lpphrysqse itdsfvefpg lkeheeiirr lhaaakvngr hlvlplqqyp

61 sltdfgdane ifiekavdlg veallgaldd anlrpsdidm iatatvtgva vpsldariag

121 rlglrpdvrr mplfglgcva gaagvarlrd ylrgapddva vlvsvelcsl typavkptvs

181 slvgtalfgd gaaavvavgd rraeqvragg pdildsrssl ypdslhimgw dvgshglrlr

241 lspdltnlie rylandvttf ldahrltkdd igawvshpgg pkvidavats lalppealel

301 twrslgeign lssasilhil rdtiekrpps gsaglmlamg pgfctelvll rwr

Return to description PKS18: English - German

LOCUS YP_177803 393 aa linear BCT 24-APR-2009

DEFINITION hypothetical protein Rv1372 [Mycobacterium tuberculosis H37Rv].

ACCESSION YP_177803

VERSION YP_177803.1 GI:57116854

DBLINK Project:224

DBSOURCE REFSEQ: accession NC_000962.2

KEYWORDS complete genome.

SOURCE Mycobacterium tuberculosis H37Rv

ORGANISM Mycobacterium tuberculosis H37Rv

Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;

Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium

tuberculosis complex.

REFERENCE 1

AUTHORS Camus,J.C., Pryor,M.J., Medigue,C. and Cole,S.T.

TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis

H37Rv

JOURNAL Microbiology (Reading, Engl.) 148 (Pt 10), 2967-2973 (2002)

PUBMED 12368430

REFERENCE 2 (residues 1 to 393)

AUTHORS Cole,S.T., Brosch,R., Parkhill,J., Garnier,T., Churcher,C.,

Harris,D., Gordon,S.V., Eiglmeier,K., Gas,S., Barry,C.E. III,

Tekaia,F., Badcock,K., Basham,D., Brown,D., Chillingworth,T.,

Connor,R., Davies,R., Devlin,K., Feltwell,T., Gentles,S.,

Hamlin,N., Holroyd,S., Hornsby,T., Jagels,K., Krogh,A., McLean,J.,

Moule,S., Murphy,L., Oliver,K., Osborne,J., Quail,M.A.,

Rajandream,M.A., Rogers,J., Rutter,S., Seeger,K., Skelton,J.,

Squares,R., Squares,S., Sulston,J.E., Taylor,K., Whitehead,S. and

Barrell,B.G.

TITLE Deciphering the biology of Mycobacterium tuberculosis from the

complete genome sequence

JOURNAL Nature 393 (6685), 537-544 (1998)

PUBMED 9634230

REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]

REFERENCE 3 (residues 1 to 393)

CONSRTM NCBI Genome Project

TITLE Direct Submission

JOURNAL Submitted (13-SEP-2001) National Center for Biotechnology

Information, NIH, Bethesda, MD 20894, USA

COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final

NCBI review. The reference sequence was derived from CAE55381.

Method: conceptual translation.

FEATURES Location/Qualifiers

source 1..393

/organism="Mycobacterium tuberculosis H37Rv"

/strain="H37Rv"

/db_xref="taxon:83332"

Protein 1..393

/product="hypothetical protein"

/function="UNKNOWN"

/calculated_mol_wt=41902

Region 32..393

/region_name="BcsA"

/note="Predicted naringenin-chalcone synthase [Secondary

metabolites biosynthesis, transport, and catabolism];

COG3424"

/db_xref="CDD:33230"

Region 32..388

/region_name="CHS_like"

/note="Chalcone and stilbene synthases; plant-specific

polyketide synthases (PKS) and related enzymes, also

called type III PKSs. PKS generate an array of different

products, dependent on the nature of the starter molecule.

They share a common chemical...; cd00831"

/db_xref="CDD:29418"

Site order(68,71..72,224,275,316..318)

/site_type="other"

/note="malonyl-CoA binding site"

/db_xref="CDD:29418"

Site order(102..103,106,147..148,153,157,163..169,173..174,

183..184,187,190..192,252,254..256,266..269,382)

/site_type="other"

/note="dimer interface"

/db_xref="CDD:29418"

Site order(175,313,346)

/site_type="active"

/db_xref="CDD:29418"

Site order(203..205,225,264..266,274..275,348,379)

/site_type="other"

/note="product binding site"

/db_xref="CDD:29418"

CDS 1..393

/locus_tag="Rv1372"

/coded_by="NC_000962.2:1544825..1546006"

/note="Rv1372, (MTCY02B12.06), len: 393 aa. Conserved

hypothetical protein, similar to several chalcone

synthases e.g. CHS2_GERHY|P48391 chalcone synthase 2 from

gerbra hybrid (402 aa), FASTA scores: opt: 511, E():

7e-26, (28.4% identity in 380 aa overlap). Also similar to

Mycobacterium tuberculosis hypothetical chalcone

synthases, Rv1665, Rv1660."

/transl_table=11

/db_xref="GeneID:886797"

ORIGIN

1 mnvsaesgap rragqrhevg laqlppappt tvavieglat gtprrvvnqs daadrvaelf

61 ldpgqrerip rvyqksritt rrmavdplda kfdvfrrepa tirdrmhlfy ehavplavdv

121 skralaglpy raaeigllvl atstgfiapg vdvaivkelg lspsisrvvv nfmgcaaamn

181 algtatnyvr ahpamkalvv cielcsvnav faddindvvi hslfgdgcaa lvigasqvqe

241 klepgkvvvr ssfsqlldnt edgivlgvnh ngitcelsen lpgyifsgva pvvtemlwdn

301 glqisdidlw aihpggpkii eqsvrslgis aelaaqswdv larfgnmlsv slifvletmv

361 qqaesakais tgvafafgpg vtvegmlfdi irr

Return to description Dpga: English - German

LOCUS CAA11765 372 aa linear BCT 02-DEC-2006

DEFINITION PCZA361.6 [Amycolatopsis orientalis].

ACCESSION CAA11765

VERSION CAA11765.1 GI:2894158

DBSOURCE embl accession AJ223998.1

KEYWORDS .

SOURCE Amycolatopsis orientalis

ORGANISM Amycolatopsis orientalis

Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;

Pseudonocardineae; Pseudonocardiaceae; Amycolatopsis.

REFERENCE 1

AUTHORS van Wageningen,A.M., Kirkpatrick,P.N., Williams,D.H., Harris,B.R.,

Kershaw,J.K., Lennard,N.J., Jones,M., Jones,S.J. and Solenberg,P.J.

TITLE Sequencing and analysis of genes involved in the biosynthesis of a

vancomycin group antibiotic

JOURNAL Chem. Biol. 5 (3), 155-162 (1998)

PUBMED 9545426

REFERENCE 2 (residues 1 to 372)

AUTHORS Kershaw,J.

TITLE Direct Submission

JOURNAL Submitted (12-FEB-1998) Sanger Centre, Hinxton, Cambridge CB10 1RQ,

England. Contact sjj@sanger.ac.uk

FEATURES Location/Qualifiers

source 1..372

/organism="Amycolatopsis orientalis"

/db_xref="taxon:31958"

/clone="PCZA361"

Protein 1..372

/product="PCZA361.6"

Region 30..372

/region_name="BcsA"

/note="Predicted naringenin-chalcone synthase [Secondary

metabolites biosynthesis, transport, and catabolism];

COG3424"

/db_xref="CDD:33230"

Region 30..369

/region_name="CHS_like"

/note="Chalcone and stilbene synthases; plant-specific

polyketide synthases (PKS) and related enzymes, also

called type III PKSs. PKS generate an array of different

products, dependent on the nature of the starter molecule.

They share a common chemical...; cd00831"

/db_xref="CDD:29418"

Site order(56,59..60,209,258,299..301)

/site_type="other"

/note="malonyl-CoA binding site"

/db_xref="CDD:29418"

Site order(90,91,132..133,138,142,148..154,158..159,168..169,

172,175..177,233,235..237,249..252,364)

/site_type="other"

/note="dimer interface"

/db_xref="CDD:29418"

Site order(160,296,329)

/site_type="active"

/db_xref="CDD:29418"

Site order(188..190,210,245,248..249,257..258,331,361)

/site_type="other"

/note="product binding site"

/db_xref="CDD:29418"

CDS 1..372

/coded_by="AJ223998.1:21434..22552"

/note="similar to chalcone synthase"

/transl_table=11

/db_xref="GOA:O52795"

/db_xref="InterPro:IPR001099"

/db_xref="InterPro:IPR011141"

/db_xref="InterPro:IPR013747"

/db_xref="UniProtKB/TrEMBL:O52795"

ORIGIN

1 mgvdvsmtvs aapaedlsvl sglteitrfa gvgtavsdts ysqpelleil diedpkirsv

61 flnsaidrrf ltlppespgg grvsepqgdl ldkhkklavd mgcraleacl ksagatlsdl

121 rhlccvtstg fltpglsali irelgidphc srsdivgmgc naglnalnvv agwsaahpge

181 lgvvlcseac saayaldgtm rtavvnslfg dgsaalavis gdrrvpgprv lkfasyiitd

241 avdamrydwd rdqdrfsffl dpqipyvvga haeivinrll sgtglrrsdi ghwlvhsggk

301 kvvdavvvnl glsrhdvrht tgvlrdygnl ssgsflfsye rlaeegvarp gdygvlmtmg

361 pgstiemali qw

Return to description Dpga: English - German

LOCUS CAC48378 372 aa linear BCT 14-DEC-2008

DEFINITION dihydroxyphenylacetic acid synthase [Amycolatopsis balhimycina].

ACCESSION CAC48378

VERSION CAC48378.1 GI:15131510

DBSOURCE embl accession Y16952.3

KEYWORDS .

SOURCE Amycolatopsis balhimycina

ORGANISM Amycolatopsis balhimycina

Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;

Pseudonocardineae; Pseudonocardiaceae; Amycolatopsis.

REFERENCE 1

AUTHORS Pelzer,S., Sussmuth,R., Heckmann,D., Recktenwald,J., Huber,P.,

Jung,G. and Wohlleben,W.

TITLE Identification and analysis of the balhimycin biosynthetic gene

cluster and its use for manipulating glycopeptide biosynthesis in

Amycolatopsis mediterranei DSM5908

JOURNAL Antimicrob. Agents Chemother. 43 (7), 1565-1573 (1999)

PUBMED 10390204

REFERENCE 2

AUTHORS Pfeifer,V., Nicholson,G.J., Ries,J., Recktenwald,J., Schefer,A.B.,

Shawky,R.M., Schroder,J., Wohlleben,W. and Pelzer,S.

TITLE A polyketide synthase in glycopeptide biosynthesis: the

biosynthesis of the non-proteinogenic amino acid

(S)-3,5-dihydroxyphenylglycine

JOURNAL J. Biol. Chem. 276 (42), 38370-38377 (2001)

PUBMED 11495926

REFERENCE 3

AUTHORS Bischoff,D., Pelzer,S., Bister,B., Nicholson,G.J., Stockert,S.,

Schirle,M., Wohlleben,W., Jung,G. and Sussmuth,R.D.

TITLE The Biosynthesis of Vancomycin-Type Glycopeptide Antibiotics-The

Order of the Cyclization Steps This work was supported by the

Deutsche Forschungsgemeinschaft (SFB 323) and by a grant of the EU

(MEGATOP, QLK3-1999-00650). R. D. S. gratefully acknowledges the

support of a Feodor-Lynen Fellowship granted by the

Alexander-von-Humboldt Stiftung. We thank Corina Bihlmaier and

Volker Pfeifer for help with transformation and Southern

hybridization, J. A. Moss (La Jolla (USA)) for critical comments on

the manuscript and Prof. Dr. M. E. Maier and Prof. Dr. H.-P.

Fiedler (Tubingen) for generous support

JOURNAL Angew. Chem. Int. Ed. Engl. 40 (24), 4688-4691 (2001)

PUBMED 12404385

REFERENCE 4

AUTHORS Puk,O., Huber,P., Bischoff,D., Recktenwald,J., Jung,G.,

Sussmuth,R.D., van Pee,K.H., Wohlleben,W. and Pelzer,S.

TITLE Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908:

function of a halogenase and a haloperoxidase/perhydrolase

JOURNAL Chem. Biol. 9 (2), 225-235 (2002)

PUBMED 11880037

REFERENCE 5

AUTHORS Recktenwald,J., Shawky,R., Puk,O., Pfennig,F., Keller,U.,

Wohlleben,W. and Pelzer,S.

TITLE Nonribosomal biosynthesis of vancomycin-type antibiotics: a

heptapeptide backbone and eight peptide synthetase modules

JOURNAL Microbiology (Reading, Engl.) 148 (PT 4), 1105-1118 (2002)

PUBMED 11932455

REFERENCE 6

AUTHORS Stegmann,E., Bischoff,D., Kittel,C., Pelzer,S., Puk,O.,

Recktenwald,J., Weist,S., Sussmuth,R. and Wohlleben,W.

TITLE Precursor-directed biosynthesis for the generation of novel

glycopetides

JOURNAL Ernst Schering Res. Found. Workshop -(51), 215-232 (2005)

REFERENCE 7

AUTHORS Pelzer,S.

TITLE Direct Submission

JOURNAL Submitted (24-MAR-1998) S. Pelzer, Universitaet Tuebingen,

Lehrstuhl Mikrobiologie-Biotechnologie, Auf der Morgenstelle 28, D-

72076 Tuebingen, FRG

REMARK revised by [6]

REFERENCE 8

AUTHORS Pelzer,S.

TITLE Direct Submission

JOURNAL Submitted (03-AUG-2001) S. Pelzer, Universitaet Tuebingen,

Lehrstuhl Mikrobiologie-Biotechnologie, Auf der Morgenstelle 28, D-

72076 Tuebingen, FRG

REMARK revised by [10]

REFERENCE 9 (residues 1 to 372)

AUTHORS Pelzer,S.

TITLE Direct Submission

JOURNAL Submitted (07-APR-2004) S. Pelzer, Universitaet Tuebingen,

Lehrstuhl Mikrobiologie-Biotechnologie, Auf der Morgenstelle 28, D-

72076 Tuebingen, FRG

FEATURES Location/Qualifiers

source 1..372

/organism="Amycolatopsis balhimycina"

/strain="DSM 5908"

/db_xref="taxon:208443"

Protein 1..372

/product="dihydroxyphenylacetic acid synthase"

/function="involved in the biosynthesis of

3,5-dihydroxyphenylglycine"

Region 30..372

/region_name="BcsA"

/note="Predicted naringenin-chalcone synthase [Secondary

metabolites biosynthesis, transport, and catabolism];

COG3424"

/db_xref="CDD:33230"

Region 30..369

/region_name="CHS_like"

/note="Chalcone and stilbene synthases; plant-specific

polyketide synthases (PKS) and related enzymes, also

called type III PKSs. PKS generate an array of different

products, dependent on the nature of the starter molecule.

They share a common chemical...; cd00831"

/db_xref="CDD:29418"

Site order(56,59..60,209,258,299..301)

/site_type="other"

/note="malonyl-CoA binding site"

/db_xref="CDD:29418"

Site order(90,91,132..133,138,142,148..154,158..159,168..169,

172,175..177,233,235..237,249..252,364)

/site_type="other"

/note="dimer interface"

/db_xref="CDD:29418"

Site order(160,296,329)

/site_type="active"

/db_xref="CDD:29418"

Site order(188..190,210,245,248..249,257..258,331,361)

/site_type="other"

/note="product binding site"

/db_xref="CDD:29418"

CDS 1..372

/gene="dpgA"

/coded_by="Y16952.3:60179..61297"

/citation=[2]

/transl_table=11

ORIGIN

1 mgvdvsmtts iepaedlsvl sglteitrfa gvgtavsass ysqsevldil dvedpkirsv

61 flnsaidrrf ltlppespgg grvsepqgdl ldkhkelavd mgcraleacl ksagatlsdl

121 rhlccvtstg fltpglsali irelgidphc srsdivgmgc naglnalnvv agwsaahpge

181 lgvvlcseac saayaldgtm rtavvnslfg dgsaalavis gdgrvpgprv lkfasyiitd

241 aldamrydwd rdqdrfsffl dpqipyvvga haeivadrll sgtglrrsdi ghwlvhsggk

301 kvidsvvvnl glsrhdvrht tgvlrdygnl ssgsflfsye rlaeegvtrp gdygvlmtmg

361 pgstiemali qw

Return to description of ArsC: English - German

LOCUS YP_002800095 409 aa linear BCT 09-JUN-2005

DEFINITION Naringenin-chalcone synthase [Azotobacter vinelandii AvOP].

ACCESSION ZP_00418326

VERSION ZP_00418326.1 GI:67156829

DBLINK Project:16

DBSOURCE REFSEQ: accession NZ_AAAU03000006.1

KEYWORDS .

SOURCE Azotobacter vinelandii

ORGANISM Azotobacter vinelandii

Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;

Pseudomonadaceae; Azotobacter.

REFERENCE 1 (residues 1 to 409)

AUTHORS Copeland,A., Lucas,S., Lapidus,A., Barry,K., Detter,C., Glavina,T.,

Hammon,N., Israni,S., Pitluck,S. and Richardson,P.

CONSRTM US DOE Joint Genome Institute (JGI-PGF)

TITLE Sequencing of the draft genome assembly of Azotobacter vinelandii

AvOP

JOURNAL Unpublished

REFERENCE 2 (residues 1 to 409)

AUTHORS Larimer,F. and Land,M.

CONSRTM US DOE Joint Genome Institute (JGI-ORNL)

TITLE Annotation of the draft genome assembly of Azotobacter vinelandii

AvOP

JOURNAL Unpublished

REFERENCE 3 (residues 1 to 409)

AUTHORS Copeland,A., Lucas,S., Lapidus,A., Barry,K., Detter,C., Glavina,T.,

Hammon,N., Israni,S., Pitluck,S. and Richardson,P.

CONSRTM US DOE Joint Genome Institute (JGI-PGF)

TITLE Direct Submission

JOURNAL Submitted (01-JUN-2005) JGI-Production Genomics Facility (JGI-PGF),

2800 Mitchell Drive, Walnut Creek, CA 94598, USA

REFERENCE 4 (residues 1 to 409)

AUTHORS DOE Joint Genome Institute.

TITLE Direct Submission

JOURNAL Submitted (26-FEB-2003) Production Genomics Facility, DOE Joint

Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA

COMMENT PREDICTED REFSEQ: This record has not been reviewed and the

function is unknown. The reference sequence was derived from

EAM05489.

URL -- http://www.jgi.doe.gov

Whole genome sequencing and draft assembly at JGI-PGF

Annotation by JGI-ORNL

Contact: Paul Richardson (microbes@cuba.jgi-psf.org).

Method: conceptual translation.

FEATURES Location/Qualifiers

source 1..409

/organism="Azotobacter vinelandii"

/strain="AvOP"

/db_xref="taxon:354"

Protein 1..409

/product="Naringenin-chalcone synthase"

/calculated_mol_wt=44811

CDS 1..409

/locus_tag="AvinDRAFT_3049"

/coded_by="NZ_AAAU03000006.1:199817..201046"

/inference="non-experimental evidence, no additional

details recorded"

/transl_table=11

/db_xref="InterPro:IPR001099"

ORIGIN

1 mndmahpnsa vladfipvql akpvpqritl eltaygfara hclsngitde egfvqvyktv

61 kekfdkyavs paqikqrqlv yfpkltdirf gdgnfdiadp epdqahlrlf dikkdprgad

121 lktrhesyak vvgkgleqmf egtleapddl ihvtcsgyla pspaermvad rgwfettvth

181 synmgcygaf paikmahgml asaqwgatpp ktrvdiahte lmsahnniae srvdniisat

241 lfsdglikys vypedelrrq glrglrilam sehllpdsad tmtgvpgshq fvmtlsplvp

301 aiikrhvraf avdllrragm dferdkdals faihpggpki vdhvqeelgl aedqvaisks

361 vflengnmss stiphilkay leeatvgtri aclgfgpglt aaglvleki

Return to description of ArsB: English - German

LOCUS YP_002800096 406 aa linear BCT 10-NOV-2009

DEFINITION Type III polyketide synthase [Azotobacter vinelandii DJ].

ACCESSION YP_002800096

VERSION YP_002800096.1 GI:226945023

DBLINK Project:16

DBSOURCE REFSEQ: accession NC_012560.1

KEYWORDS .

SOURCE Azotobacter vinelandii DJ

ORGANISM Azotobacter vinelandii DJ

Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;

Pseudomonadaceae; Azotobacter.

REFERENCE 1 (residues 1 to 406)

CONSRTM NCBI Genome Project

TITLE Direct Submission

JOURNAL Submitted (14-APR-2009) National Center for Biotechnology

Information, NIH, Bethesda, MD 20894, USA

REFERENCE 2 (residues 1 to 406)

AUTHORS Setubal,J.C., Almeida,N.F., Goldman,B., Dean,D.R., Dixon,R., Dos

Santos,P., Ertesvag,H., Espin,G.E., Goodner,B.W., Imperial,J.,

Kennedy,C., Larson,T., Paulsen,I., Rosser,J., Rubio,L.M.,

Segura,D., Slater,S., Valla,S., Mesquita,L.P., Viana,C.J. and

Wood,D.

CONSRTM Azotobacter vinelandii Consortium

TITLE Direct Submission

JOURNAL Submitted (15-SEP-2008) Virginia Bioinformatics Institute, Virginia

Polytechnic Institute and State University, Washington Street, MC

0477, Blacksburg, VA 24061-0477, USA

COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final

NCBI review. The reference sequence was derived from ACO79121.

Method: conceptual translation.

FEATURES Location/Qualifiers

source 1..406

/organism="Azotobacter vinelandii DJ"

/strain="DJ; ATCC BAA-1303"

/culture_collection="ATCC:BAA-1303"

/db_xref="taxon:322710"

/note="strain coidentity: DJ = ATCC BAA-1303"

Protein 1..406

/product="Type III polyketide synthase"

/calculated_mol_wt=44829

Region 7..403

/region_name="CHS_like"

/note="Chalcone and stilbene synthases; plant-specific

polyketide synthases (PKS) and related enzymes, also

called type III PKSs. PKS generate an array of different

products, dependent on the nature of the starter molecule.

They share a common chemical...; cd00831"

/db_xref="CDD:29418"

Site order(54,57..58,239,290,334..336)

/site_type="other"

/note="malonyl-CoA binding site"

/db_xref="CDD:29418"

Site order(107..108,111,156..157,162,166,172..178,181..182,

191..192,195,198..200,267,269..271,281..284,397)

/site_type="other"

/note="dimer interface"

/db_xref="CDD:29418"

Site order(183,331,364)

/site_type="active"

/db_xref="CDD:29418"

Site order(217..219,240,279..281,289..290,366,394)

/site_type="other"

/note="product binding site"

/db_xref="CDD:29418"

CDS 1..406

/gene="arsB"

/locus_tag="Avin_29550"

/coded_by="complement(NC_012560.1:3044882..3046102)"

/transl_table=11

/db_xref="GeneID:7761856"

ORIGIN

1 mssphnavlt gftpvqlakp vpqaltlels ayafarayci kngvgtddea gfakvyqsvk

61 ekfdkyalss aqikrrqlif fpkvsdihfa nghvdiaape haylklydma tdprgsdlkv

121 rhesyakvvd qglermfqds aeapddlihv tcsgylspsp vermaadrgw fettvthsyh

181 mgcygafpai kmahgmlsss rfgvtpvkhr vdivhtells ahnnivdara eniitmtlfa

241 dglikysvls eeelhrqggh glrvlamneh llpdsademt wvpgshqflm tltpmvpvvi

301 krhvrdfvvk lleragidye rerleltfai hpggpkiveh iqedlglsde qvaisksvfl

361 engnmssati philkqvlee vdvgtrvlcl gfgpgltvtg mvleki

Return to description of germicidin biosynthesis: English - German

LOCUS NP_631277 389 aa linear BCT 30-APR-2009

DEFINITION polyketide synthase [Streptomyces coelicolor A3(2)].

ACCESSION NP_631277

VERSION NP_631277.1 GI:21225498

DBLINK Project:242

DBSOURCE REFSEQ: accession NC_003888.3

KEYWORDS complete genome.

SOURCE Streptomyces coelicolor A3(2)

ORGANISM Streptomyces coelicolor A3(2)

Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;

Streptomycineae; Streptomycetaceae; Streptomyces.

REFERENCE 1 (residues 1 to 389)

AUTHORS Bentley,S.D., Chater,K.F., Cerdeno-Tarraga,A.M., Challis,G.L.,

Thomson,N.R., James,K.D., Harris,D.E., Quail,M.A., Kieser,H.,

Harper,D., Bateman,A., Brown,S., Chandra,G., Chen,C.W., Collins,M.,

Cronin,A., Fraser,A., Goble,A., Hidalgo,J., Hornsby,T., Howarth,S.,

Huang,C.H., Kieser,T., Larke,L., Murphy,L., Oliver,K., O'Neil,S.,

Rabbinowitsch,E., Rajandream,M.A., Rutherford,K., Rutter,S.,

Seeger,K., Saunders,D., Sharp,S., Squares,R., Squares,S.,

Taylor,K., Warren,T., Wietzorrek,A., Woodward,J., Barrell,B.G.,

Parkhill,J. and Hopwood,D.A.

TITLE Complete genome sequence of the model actinomycete Streptomyces

coelicolor A3(2)

JOURNAL Nature 417 (6885), 141-147 (2002)

PUBMED 12000953

REFERENCE 2 (residues 1 to 389)

AUTHORS Redenbach,M., Kieser,H.M., Denapaite,D., Eichner,A., Cullum,J.,

Kinashi,H. and Hopwood,D.A.

TITLE A set of ordered cosmids and a detailed genetic and physical map

for the 8 Mb Streptomyces coelicolor A3(2) chromosome

JOURNAL Mol. Microbiol. 21 (1), 77-96 (1996)

PUBMED 8843436

REFERENCE 3 (residues 1 to 389)

CONSRTM NCBI Genome Project

TITLE Direct Submission

JOURNAL Submitted (28-MAY-2002) National Center for Biotechnology

Information, NIH, Bethesda, MD 20894, USA

REFERENCE 4 (residues 1 to 389)

AUTHORS Bentley,S.D.

TITLE Direct Submission

JOURNAL Submitted (09-MAY-2002) Sanger Institute, Wellcome Trust Genome

Campus, Hinxton, Cambridge CB10 1SA, United Kingdom

COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final

NCBI review. The reference sequence was derived from CAB94644.

Method: conceptual translation.

FEATURES Location/Qualifiers

source 1..389

/organism="Streptomyces coelicolor A3(2)"

/strain="A3(2)"

/db_xref="taxon:100226"

Protein 1..389

/product="polyketide synthase"

/calculated_mol_wt=41568

Region 2..384

/region_name="CHS_like"

/note="Chalcone and stilbene synthases; plant-specific

polyketide synthases (PKS) and related enzymes, also

called type III PKSs. PKS generate an array of different

products, dependent on the nature of the starter molecule.

They share a common chemical...; cd00831"

/db_xref="CDD:29418"

Site order(41..42,225,272,315..317)

/site_type="other"

/note="malonyl-CoA binding site"

/db_xref="CDD:29418"

Site order(102..103,106,147..148,153,157,163..169,173..174,

183..184,187,190..192,249,251..253,263..266,380)

/site_type="other"

/note="dimer interface"

/db_xref="CDD:29418"

Site order(175,312,346)

/site_type="active"

/db_xref="CDD:29418"

Site order(203..205,226,261..263,271..272,348,377)

/site_type="other"

/note="product binding site"

/db_xref="CDD:29418"

CDS 1..389

/locus_tag="SCO7221"

/gene_synonym="SC2H12.20c"

/coded_by="complement(NC_003888.3:8026306..8027475)"

/note="SC2H12.20c, possible polyketide synthase, len: 389

aa. Weakly similar to several proteins from Eukaryotes and

Prokaryotes involved in secondary metabolism e.g.

Hydrangea macrophylla SW:CHSY_HYDMC(EMBL:AB011467)

chalcone synthase (EC 2.3.1.74) a secondary plant

metabolite (389 aa), fasta scores opt: 294 z-score: 333.6

E(): 4.1e-11 28.4% identity in 282 aa overlap and

Pseudomonas fluorescens TR:Q51725(EMBL:U41818) polyketide

synthase PhlD (349 aa), fasta scores opt: 433 z-score:

489.6 E(): 8.5e-20 26.4% identity in 386 aa overlap.

Contains a Pfam match to entry PF00195 Chal_stil_synt,

Chalcone and stilbene synthases."

/transl_table=11

/db_xref="GeneID:1102659"

ORIGIN

1 maaylcapav ihgehsvetr eiveevrgrh phapwaprid giaastgies rgwmlpleaa

61 vapggggdlg aarealvrdg fteqdanrai aalkavpasq tvqertapaw eavqaygera

121 argalqiagl dvadvdclit snsttpalpg ldvalanrlp lrgdtmllpa tqwacvagtr

181 slalaadlva adpdrvvlvv isealsttyq paddtlesli vrllfadtav aavvtgrprp

241 esvlrldaaw hhtlpgtrdl hrletradgt hfvmdrrgpr avqetvtamw ewlrvryedd

301 psswhpdvll ahpggtrvle ymeqtmpdew psgllsysrd sytsgnrgga avfdilrrah

361 dagqktgsra vlyaaapglt atalegewl

-> The sequence is the same as in CAE07508

Return to description: English - German

LOCUS NP_897086 362 aa linear BCT 24-APR-2009

DEFINITION putative chalcone synthase [Synechococcus sp. WH 8102].

ACCESSION NP_897086

VERSION NP_897086.1 GI:33865527

DBLINK Project:230

DBSOURCE REFSEQ: accession NC_005070.1

KEYWORDS complete genomes.

SOURCE Synechococcus sp. WH 8102

ORGANISM Synechococcus sp. WH 8102

Bacteria; Cyanobacteria; Chroococcales; Synechococcus.

REFERENCE 1 (residues 1 to 362)

AUTHORS Palenik,B., Brahamsha,B., Larimer,F.W., Land,M., Hauser,L.,

Chain,P., Lamerdin,J., Regala,W., Allen,E.E., McCarren,J.,

Paulsen,I., Dufresne,A., Partensky,F., Webb,E.A. and Waterbury,J.

TITLE The genome of a motile marine Synechococcus

JOURNAL Nature 424 (6952), 1037-1042 (2003)

PUBMED 12917641

REFERENCE 2 (residues 1 to 362)

CONSRTM NCBI Genome Project

TITLE Direct Submission

JOURNAL Submitted (10-SEP-2004) National Center for Biotechnology

Information, NIH, Bethesda, MD 20894, USA

REFERENCE 3 (residues 1 to 362)

CONSRTM NCBI Microbial Genomes Annotation Project

TITLE Direct Submission

JOURNAL Submitted (25-JUN-2001) National Center for Biotechnology

Information, NIH, Bethesda, MD 20894, USA

COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final

NCBI review. The reference sequence was derived from CAE07508.

Method: conceptual translation.

FEATURES Location/Qualifiers

source 1..362

/organism="Synechococcus sp. WH 8102"

/strain="WH 8102"

/db_xref="taxon:84588"

Protein 1..362

/product="putative chalcone synthase"

/EC_number="2.3.1.74"

/calculated_mol_wt=38730

Region 1..361

/region_name="BcsA"

/note="Predicted naringenin-chalcone synthase [Secondary

metabolites biosynthesis, transport, and catabolism];

COG3424"

/db_xref="CDD:33230"

Region 2..359

/region_name="CHS_like"

/note="Chalcone and stilbene synthases; plant-specific

polyketide synthases (PKS) and related enzymes, also

called type III PKSs. PKS generate an array of different

products, dependent on the nature of the starter molecule.

They share a common chemical...; cd00831"

/db_xref="CDD:29418"

Site order(39,42..43,202,250,291..293)

/site_type="other"

/note="malonyl-CoA binding site"

/db_xref="CDD:29418"

Site order(80..81,84,125..126,131,135,141..147,151..152,

161..162,165,168..170,227,229..231,241..244,353)

/site_type="other"

/note="dimer interface"

/db_xref="CDD:29418"

Site order(153,288,321)

/site_type="active"

/db_xref="CDD:29418"

Site order(181..183,203,239..241,249..250,323,350)

/site_type="other"

/note="product binding site"

/db_xref="CDD:29418"

CDS 1..362

/locus_tag="SYNW0993"

/coded_by="NC_005070.1:990655..991743"

/inference="non-experimental evidence, no additional

details recorded"

/transl_table=11

/db_xref="GeneID:1731324"

ORIGIN

1 mplilhgigt avpsrrlsqa davqvahrin aetpeqvrlm triyqktkvl srgsvllekd

61 gddgtiqerl sfygeespgt aermqafedh agelaleaaa kalsdsdisa taithlvtvs

121 ctgfqspgvd lfliekldls psvqrthigf mgchaalngl rvahafaemd pkavvllcav

181 elcslhmayg whpeqvvana lfadgaaavv asvnpspthq tlalrrsgsm vipnssdlmh

241 weigdhgfam glsplvpetv gaallpwlrd wlkeqaidle avtswavhpg gpkilstcae

301 vlsldpgllh esrgilqdhg nmssatilfi lerlrrrecs gpclalafgp glsaevalfd

361 fq

-> The sequence is the same as in NP_897086

Return to description: English - German

LOCUS CAE07508 362 aa linear BCT 05-MAR-2008

DEFINITION putative chalcone synthase [Synechococcus sp. WH 8102].

ACCESSION CAE07508

VERSION CAE07508.1 GI:33632696

DBSOURCE embl accession BX569691.1

KEYWORDS .

SOURCE Synechococcus sp. WH 8102

ORGANISM Synechococcus sp. WH 8102

Bacteria; Cyanobacteria; Chroococcales; Synechococcus.

REFERENCE 1 (residues 1 to 362)

AUTHORS Palenik,B., Brahamsha,B., Larimer,F.W., Land,M., Hauser,L.,

Chain,P., Lamerdin,J., Regala,W., Allen,E.E., McCarren,J.,

Paulsen,I., Dufresne,A., Partensky,F., Webb,E.A. and Waterbury,J.

TITLE The genome of a motile marine Synechococcus

JOURNAL Nature 424 (6952), 1037-1042 (2003)

PUBMED 12917641

REFERENCE 2

AUTHORS McCarren,J. and Brahamsha,B.

TITLE SwmB, a 1.12-megadalton protein that is required for nonflagellar

swimming motility in Synechococcus

JOURNAL J. Bacteriol. 189 (3), 1158-1162 (2007)

PUBMED 17158680

REFERENCE 3 (residues 1 to 362)

AUTHORS Larimer,F. and Palenik,B.

CONSRTM Synechococcus genome consortium

TITLE Direct Submission

JOURNAL Submitted (01-JUL-2003) Larimer, F., Submitted on behalf of the

Synechococcus genome consortium, the DOE Joint Genome Institute,

Production Genomics Facility, 2800 Mitchell Drive, Walnut Creek, CA

94598, USA, and the Genome Analysis Group, Oak Ridge National

Laboratory, 1060 Commerce Park Drive, Oak Ridge, TN 37831, USA;

larimerfw@ornl.gov

FEATURES Location/Qualifiers

source 1..362

/organism="Synechococcus sp. WH 8102"

/strain="WH8102"

/db_xref="taxon:84588"

Protein 1..362

/product="putative chalcone synthase"

/EC_number="2.3.1.74"

Region 1..361

/region_name="BcsA"

/note="Predicted naringenin-chalcone synthase [Secondary

metabolites biosynthesis, transport, and catabolism];

COG3424"

/db_xref="CDD:33230"

Region 2..359

/region_name="CHS_like"

/note="Chalcone and stilbene synthases; plant-specific

polyketide synthases (PKS) and related enzymes, also

called type III PKSs. PKS generate an array of different

products, dependent on the nature of the starter molecule.

They share a common chemical...; cd00831"

/db_xref="CDD:29418"

Site order(39,42..43,202,250,291..293)

/site_type="other"

/note="malonyl-CoA binding site"

/db_xref="CDD:29418"

Site order(80..81,84,125..126,131,135,141..147,151..152,

161..162,165,168..170,227,229..231,241..244,353)

/site_type="other"

/note="dimer interface"

/db_xref="CDD:29418"

Site order(153,288,321)

/site_type="active"

/db_xref="CDD:29418"

Site order(181..183,203,239..241,249..250,323,350)

/site_type="other"

/note="product binding site"

/db_xref="CDD:29418"

CDS 1..362

/locus_tag="SYNW0993"

/coded_by="BX569691.1:292339..293427"

/inference="non-experimental evidence, no additional

details recorded"

/transl_table=11

/db_xref="GOA:Q7U7I9"

/db_xref="InterPro:IPR001099"

/db_xref="InterPro:IPR011141"

/db_xref="InterPro:IPR012328"

/db_xref="UniProtKB/TrEMBL:Q7U7I9"

ORIGIN

1 mplilhgigt avpsrrlsqa davqvahrin aetpeqvrlm triyqktkvl srgsvllekd

61 gddgtiqerl sfygeespgt aermqafedh agelaleaaa kalsdsdisa taithlvtvs

121 ctgfqspgvd lfliekldls psvqrthigf mgchaalngl rvahafaemd pkavvllcav

181 elcslhmayg whpeqvvana lfadgaaavv asvnpspthq tlalrrsgsm vipnssdlmh

241 weigdhgfam glsplvpetv gaallpwlrd wlkeqaidle avtswavhpg gpkilstcae

301 vlsldpgllh esrgilqdhg nmssatilfi lerlrrrecs gpclalafgp glsaevalfd

361 fq

LOCUS YP_002596744 356 aa linear BCT 27-FEB-2009

DEFINITION phloroisovalerophenone synthase [Cyanobium sp. PCC 7001].

ACCESSION YP_002596744

VERSION YP_002596744.1 GI:223491912

DBSOURCE REFSEQ: accession NW_002243451.1

KEYWORDS .

SOURCE Cyanobium sp. PCC 7001

ORGANISM Cyanobium sp. PCC 7001

Bacteria; Cyanobacteria; Chroococcales; Cyanobium.

REFERENCE 1 (residues 1 to 356)

CONSRTM NCBI Genome Project

TITLE Direct Submission

JOURNAL Submitted (27-FEB-2009) National Center for Biotechnology

Information, NIH, Bethesda, MD 20894, USA

REFERENCE 2 (residues 1 to 356)

AUTHORS Lily,E., Ferriera,S., Johnson,J., Kravitz,S., Beeson,K., Sutton,G.,

Rogers,Y.-H., Friedman,R., Frazier,M. and Venter,J.C.

TITLE Direct Submission

JOURNAL Submitted (08-JUL-2008) J. Craig Venter Institute, 9704 Medical

Center Drive, Rockville, MD 20850, USA

COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final

NCBI review. The reference sequence was derived from EDY38841.

Method: conceptual translation.

FEATURES Location/Qualifiers

source 1..356

/organism="Cyanobium sp. PCC 7001"

/strain="PCC 7001"

/db_xref="taxon:180281"

Protein 1..356

/product="phloroisovalerophenone synthase"

/EC_number="2.3.1.156"

/calculated_mol_wt=37139

Region 4..354

/region_name="BcsA"

/note="Predicted naringenin-chalcone synthase [Secondary

metabolites biosynthesis, transport, and catabolism];

COG3424"

/db_xref="CDD:33230"

Region 5..353

/region_name="CHS_like"

/note="Chalcone and stilbene synthases; plant-specific

polyketide synthases (PKS) and related enzymes, also

called type III PKSs. PKS generate an array of different

products, dependent on the nature of the starter molecule.

They share a common chemical...; cd00831"

/db_xref="CDD:29418"

Site order(39,42..43,187,234,275..277)

/site_type="other"

/note="malonyl-CoA binding site"

/db_xref="CDD:29418"

Site order(65..66,69,110..111,116,120,126..132,136..137,

146..147,150,153..155,211,213..215,225..228,347)

/site_type="other"

/note="dimer interface"

/db_xref="CDD:29418"

Site order(138,272,305)

/site_type="active"

/db_xref="CDD:29418"

Site order(166..168,188,223..225,233..234,307,344)

/site_type="other"

/note="product binding site"

/db_xref="CDD:29418"

CDS 1..356

/locus_tag="CPCC7001_1720"

/coded_by="NW_002243451.1:289688..290758"

/note="[I] COG0332 3-oxoacyl-[acyl-carrier-protein]

synthase III"

/transl_table=11

/db_xref="GeneID:7412657"

ORIGIN

1 mglilrglgt avperrlsqe qtldlapqma aatlrqqrll rriylrsgvd grhcvpllaa

61 tnpstaermr hyrteavpla lqacrraled aaiapdaith lvtvsctgfs apgvdlalie

121 avplrpdvar thvgfmgchg alnglrvaqa fveadpracv llcavelcsl hlqegwnpdh

181 ivanalfadg agavvavaar peagrlrlra cgstvvpasa damawiiedh gfsmalsarv

241 pgliaarlrp wleawlaghg lslpaiqhwa vhpggprils avlesaglep grldgsrevl

301 rqygnmssat vlfilqrllg paaapgapga gaasgpclal gfgpgltvea allelp

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File History:

24.07.2009: File established