Websites of the Schröder Group

Plant
(with links to Wikipedia)

References and short comments
 

Arabidopsis thaliana

 

Yu et al., 2006;
-> why Arabidopsis? The only justification seems to be that this tested the first STS from a monocot: Sorghum bicolor.

Alfalfa (Medicago sativa)

 

Hipskind et al., 2000;
-> intended as phytoalexin: but resveratrol should have the same beneficial effects in cattle as in humans?

Apple (Malus domestica)
 

Szankowski et al., 2003; Rühmann et al., 2006;
-> for apples as sources of resveratrol

Grape (Vitis vinifera)
 

Fan et al., 2008; Coutos-Thévenot et al., 2001;
-> for disease resistance (role as phytoalexin)

Hop (Humulus lupulus)





 

Schwekendiek et al., 2007;
-> According to the authors, "sts transgenic hop plants could display enhanced pathogen resistance against microbial pathogens, exhibit new beneficial properties for health, and open new venues for metabolic engineering": how about bringing via these plants resveratrol into beer?
-> Actually, hop cones appear to contain resveratrol (most in the form of piceid, the sucrose derivative) anyway: Callemien et al., 2005; Jerkovic et al., 2005; Jerkovic and Collin, 2007; Jerkovic and Collin, 2008.

Kiwi (Actinidia deliciosa)
 

Kobayashi et al., 2000;
-> apparently no effect on disease resistance, but the resveratrol in the fruits might have beneficial effects on humans

Lettuce (Lactuca sativa)
 

Liu et al., 2006;
-> food supplementation with resveratrol !

Monocots


   - Barley (Hordeum vulgare)
   - Rice (Oryza sativa)
   - Wheat (Triticum spp.)
 

-> apparently for phytoalexin formation: are there recent attempts to get resveratrol into the seeds?

Leckband and Lörz, 1998; 
Stark-Lorenzen et al., 1997; Tian et al., 1998, 
Leckband and Lörz, 1998; Fettig and Hess, 1999;Liang et al., 2000;  Serazetdinova et al., 2005;
 

Papaya (Carica papaya)
 

Zhu et al., 2004;
-> disease resistance

Peas (Pisum sativum)
 

Richter et al., 2006;

-> disease resistance

Rapeseed (Brassica napus L.)
 

Hüsken et al., 2005;
-> supplementation of the seeds with resveratrol !

Strawberry (Fragraria)
 

Hanhineva et al., 2009
-> no stilbenes detected, although changes in metabolite profile

Monterey Pine = Radiata pine (Pinus radiata)
 

Höfig et al., 2006;
-> interesting approach to genetically engineered nuclear male sterility!
 

Rehmannia glutinosa

 

Lim et al., 2005;
-> this medicinal plant contains traces of resveratrol type compounds: the STS from peanut was used to increase resveratrol amounts

Tobacco

 

Hain et al., 1990;  1993; Fischer et al., 1997; Zhong et al., 2004; Schmidlin et al., 2008;
-> pathogen resistance (who would eat tobacco? However, there are also tobacco chewers).
-> Fischer et al.: Effect of resveratrol on male sterility!

Tomato (Lycopersicon esculentum)



 

Thomzik et al., 1997; Giovinazzo et al., 2005; Morelli et al., 2006; Schijlen et al., 2006; Nicoletti et al., 2007; D'Introno et al., 2009; Ma et al., 2009;
->These seem to be the most advanced experiments to genetically engineer resveratrol biosynthesis specifically into fruits!
-> Interestingly, one publication even claimed that resveratrol glucoside (piceid) is present in normal tomato, but only in the skin of the fruit, not in the flesh (Ragab et al., 2006),

White poplar (Populus alba)
and
Aspen (Populus tremula)
 

Giorcelli et al., 2004;
-> much resveratrol-glycoside, but no increased resistance against rust disease
Seppänen et al., 2004;
-> resistance against fungi

Human cell cultures


 

Zhang et al., 2006
-> recent work shows that the pathway from the amino acids phenylalanine/tyrosine to resveratrol can be transferred by genetic manipulation to human cell cultures. No precursor feeding was necessary to obtain resveratrol in the cells !!!

Yeast (e.g. Saccharomyces cerevisiae)



 

Gonzalez-Candelas et al., 2000; Becker et al., 2003, Beekwilder et al., 2006, Zhang et al., 2006; Trantas et al., 2009;
->The expression of the pathway from phenylalanine to resveratrol also works with yeasts: The interesting aspect in this is that using such strains in beer or wine fermentation could introduce resveratrol into beer and white wine !!!

E. coli



 

Watts et al., 2006; Beekwilder et al., 2006; Katsuyama et al., 2007a; Katsuyama et al., 2007b; Horinouchi 2009; 
-> And how about E. coli? These bacteria were not only used to get recombinant chalcone and stilbene synthases (for functional investigations in vitro), but they can also be engineered to produce stilbenes in vivo: Would it not be a hilarious idea to have such a supplement in your intestinal flora?